List of Publications:

Journal Articles

1. Siu Chung Ha, Ya-Hui Tsai, Chee-Chee Koh, Shinn-Gwo Hong, Yun Chen, Chao-Ling Yao (2024, Feb). Blood biomarkers to distinguish complicated and uncomplicated appendicitis in pediatric patients. Journal of the Formosan Medical Association, 10.1016/j.jfma.2024.01.023. [First Author]

2. Chen-Huan Yu, Yun Chen, Chien-Chen Tsai, Tzong-Hsi Lee, Ya-Hui Tsai, Chen-Shuan Chung (2024 Feb). Magnifying Endoscopy With Narrow Band Imaging for Graft Failure and Disease Recurrence in Patients With Crohn Disease After Intestinal Transplantation: 2 Case Reports. Transplant Proceedings. 2024 Feb 8:S0041-1345(24)00060-5.

3. Yun Chen, Sheng-Hong Tseng, Chih-Yen Chen, Ya-Hui Tsai (2023, Sep). Application of Intestinal Barrier Molecules in the Diagnosis of Acute Cellular Rejection After Intestinal Transplantation. Tranplant International, 36, 11595. [Corresponding Author]

4. Chee-Chee Koh, Huang-Wen Tsai, Siu-Chung Ha, Ya-Hui Tsai, Yun Chen (2023,May). Efficacy of same venous route Hickman catheter replacement in patients with intestinal failure. Journal of Formosan Medical Association, 122(5), 419-426.

5. Siu Chung Ha, Ya-Hui Tsai, Shinn-Gwo Hong, Yun Chen*, Chao-Ling Yao (2023, May). Hyaluronic Acid Stimulated Enterocytic Differentiation of Intestinal Stem Cells and Enhanced Enteroid Grafting on Scaffolds. Biotechnology and Bioprocess Engineering , 28, 451-458. [First Author]

6. You-Sheng Lin, Yun Chen, Ya-Hui Tsai, Sheng-Hong Tseng, Kuen-Song Lin (2021, Jul). In vivo imaging of neuroblastomas using GD2-targeting graphene quantum dots. Journal of Pediatric Surgery, 56(7): 1227-1232.

7. Yun Chen, Ya-Hui Tsai, Sheng-Hong Tseng (2021, Feb). Regulation of ZMYND8 to Treat Cancer. Molecules, 26(4), 1083.

8. Yun Chen, Huang-Wen Tsai, Ya-Hui Tsai, Sheng-Hong Tseng (2020, Nov). VS[1]5584, a PI3K/mTOR dual inhibitor, exerts antitumor effects on neuroblastomas in vitro and in vivo. Journal of Pediatric Surgery, 56 (8), 1441-1448.

9. Yun Chen, Ya-Hui Tsai, Bor-Jiun Tseng, Sheng-Hong Tseng (2019, Aug). Influence of Growth Hormone and Glutamine on Intestinal Stem Cells: A Narrative Review. Nutrients, 11(8), 1941.

10. Yun Chen, Ya-Hui Tsai, Sheng-Hong Tseng (2019, Jul). Regulation of BS69 Expression in Cancers. Anticancer Research, 39(7), 3347-3351.

11. Yun Chen, Sheng-Hong Tseng, Chee-Chee Koh, Chen-Shuan Chung, Chia-Chi Weng, Ya-Hui Tsai (2018, Nov). The Zinc Deficiency and Long-Term Outcome in the Cases after Isolated Intestinal Transplantation in Taiwan. Transplantation Proceedings, 50(9), 2771-2774. [Corresponding Author]

12. Yun Chen, Xiang-Qin Yang, Bor-Yuan Tseng, Ya-Hui Tsai, Sheng-Hong Tseng, Cheng-Hung Lee, Chao-Ling Yao (2018, Nov). Deferoxamine preconditioning activated hypoxia-inducible factor-1α and MyD88-dependent Toll-like receptor 4 signaling in intestinal stem cells. Journal of Pediatric Surgery, 53(11), 2349-2356.

13. Yun Chen, Cheng-Hung LEe, Bor-Yuan Tseng, Ya-Hui Tsai, Huan-Wen Tsai, Chao-Ling Yao, Sheng-Hong Tseng (2018, Mar). AZD8055 Exerts Antitumor Effects on Colon Cancer Cells by Inhibiting mTOR and Cell-cycle Progression. Anticancer Research, 38 (3), 1445-1454.

14. Yun Chen, Sheng-Hong Tseng, Chao-Ling Yao, Chuan Li, Ya-Hui Tsai (2018, Mar). Distinct Effects of Growth Hormone and Glutamine on Activation of Intestinal Stem Cells. Journal of Parenteral and Enteral Nutrition, 42 (3), 642-651. [Corresponding Author]

15. Vincent Chan, Chuan Li, Ya-Hui Tsai, YH Tseng, Yun Chen (2017, Oct). Cyclopropylamine modified plasma polymerised poly (methyl methacrylate) thin films for cell culture. International Journal of Nanotechnology, 14(12), 1045-1065.

16. Yun Chen, Ya-Hui Tsai, Sheng-Hong Tseng (2017, Jan). HDAC Inhibitors and RECK Modulate Endoplasmic Reticulum Stress in Tumor Cells. International Journal of Molecular Sciences, 18(2),258-266.

17. Yun Chen, Ya-Hui Tsai, Bor-Jiun Tseng, Hsin-Yen Pan, Sheng-Hong Tseng (2016, Nov). Suppression of miR-19b enhanced the cytotoxic effects of mTOR inhibitors in human neuroblastoma cells. Journal of Pediatric Surgery , 51(11):1818-1825.

18. Yun Chen, Ya-Hui Tsai, Sheng-Hong Tseng (2016, Nov). Regulation of the expression of Cytoplasmic Polyadenylation Element Binding Proteins for the Treatment of Cancer. Anticancer Research, 36 (11):5673-5680.

19. Khalilalrahman Dehvari, Yun Chen, Ya-Hui Tsai, Sheng-Hong Tseng, Kuen-Song Lin (2016, Sep). Superparamagnetic Iron Oxide Nanorod Carriers for Paclitaxel Delivery in the Treatment and Imaging of Colon Cancer in Mice. Journal of Biomedical Nanotechnology , 12(9): 1734-1745.

20. Yun Chen, Ya-Hui Tsai, Sheng-Hong Tseng (2016, Mar). Selenite stimulates the proliferation of intestinal stem cells with elevated anti-oxidative activity. Transplantation Proceedings, 48 (2):507-511.

21. Wei-Ting Kuo, Tsung-Chun Lee, Hsun-Yuan Yang, Chi-Yun Chen, Yin-Chung Au, Yen-Zhen Lu, Li-Ling Wu, Shu-Chen Wei, Yen-Hsuan Ni, Been-Ren Lin, Yun Chen, Ya-Hui Tsai, John Kung, Fuu Sheu, and Long-Wei Lin, Linda Yu (2015, Oct). LPS receptor subunits play antagonistic roles in epithelial apoptosis and colonic carcinogenesis. Cell Death and Differentiation, 22(10), 1590-1604.

22. Steven S-S Wang, Su-Chun How, Yun-Duan Chen, Ya-Hui Tsai, Jeng-Shiung Jan (2015, Jul). Bioactive saccharide-conjugated polypeptide micelles for acid triggered doxorubicin delivery. Journal of Materials Chemistry B, 3(26): 5220-5231.

23. Yun Chen, Shih-Hua Lee, Ya-Hui Tsai, and Sheng-Hong Tseng (2014, Mar). Ischemic preconditioning increased the intestinal stem cell activities in the intestinal crypts in mice. Journal of Surgical Research, 187(1), 85-93. [Corresponding Author]

24. Yun Chen, Ya-Hui Tsai, and Sheng-Hong Tseng* (2013, Nov). RECK regulated endoplasmic reticulum stress response and enhanced cisplatin-induced cell death in neuroblastoma cells. Surgery, 154: 968-979.

25. Yun Chen, Ya-Hui Tsai, and Sheng-Hong Tseng* (2013, Jan). Inhibition of cyclin-dependent kinase 1-induced cell death in neuroblastoma cells through the microRNA-34a-MYCN-survivin pathway. Surgery, 153:4-16.

26. Yun Chen, Ya-Hui Tsai*, Yu Fang, and Sheng-Hong Tseng* (2012, Oct). Micro-RNA- 21 regulates the sensitivity to cisplatin in human neuroblastoma cells. Journal of Pediatric Surgery, 47:1797-1805. [Corresponding Author]

27. Yun Chen, Ya-Hui Tsai, and Sheng-Hong Tseng* (2012, Aug). Valproic acid affected the survival and invasiveness of human glioma cells through diverse mechanisms. Journal of Neuro-oncology, 109:23-33.

28. Yun Chen, Ya-Hui Tsai, and Sheng-Hong Tseng* (2011, Sep). The potential of tetrandrine as a protective agent for ischemic stroke . Molecules, 16:8020-8032.

29. Yun Chen, Ya-Hui Tsai, and Sheng-Hong Tseng* (2011, Jun). Combined valproic acid and celecoxib treatment induced synergistic cytotoxicity and apoptosis in neuroblastoma cells. Anticancer Research, 31:2231-2239.

30. Yin-Ju Chen, Yu-Hsuan Chen, Lu-Ping Chow, Ya-Hui Tsai, Pei-Hong Chen, Chi-Ying F Huang, Wei-Tzu Chen, Lih-Hwa Hwang* (2010, Sep). Heat shock protein 72 is associated with the hepatitis C virus replicase complex and enhances viral RNA replication. Journal of Biological Chemistry, 285 (36): 28183-28190.

31. Ya-Hui Tsai, Wan-Fen Kuang, Tsai-Yi Lu, Jia-Horng Kao, Ming-Yang Lai, Chun-Jen Liu, Pei-Jer Chen, and Lih-Hwa Hwang* (2008, Nov). The non-structural 5A protein of hepatitis C virus exhibits genotypic differences in interferon antagonism. Journal of Hepatology, 49:899-907. [First Author] (博士論文發表).

Book Chapter

1. Yun Chen, Chuan Li, Ya-Hui Tsai, Sheng-Hong Tseng. Intestinal Crypt Organoid: Isolation of Intestinal Stem Cells, In Vitro Culture, and Optical Observation. Methods in molecular biology (Clifton, NJ) (ISBN: 1064-3745). Springer Nature. Mar, 2017. MOST 104-2314-B-418-015.

Conference Papers

1. Yun Chen, Ya-Hui Tsai (2023.Oct). Lutein treatment enhanced the antioxidant environment in intestinal stem cells by modulating the expression of SOD3 and GPX5. 56th Annual Meeting of the Pacific Association of Pediatric Surgeons (PAPS 2023), Bali, Indonesia.

2. Yun Chen, Ya-Hui Tsai (2022.Sep). COH29, a ribonucleotide reductase inhibitor, exhibits in vitro and in vivo anti-tumor effects on neuroblastoma cells. 55th Annual Meeting of the Pacific Association of Pediatric Surgeons (PAPS 2022), Quito, Ecuador / Virtual

3. Yun Chen, Chia-Chi Weng, Chee-Chee Koh, Ya-Hui Tsai (2020. Nov). Application of intestinal barrier molecule as diagnosing tool for acute cellular rejection after intestinal transplantation. 53rd Annual Meeting of the Pacific Association of Pediatric Surgeons (PAPS 2020), virtual Meeting

4. Ya-Hui Tsai, Yun Chen (2019, Mar). Curcumin Regulates the Regenerative Activities of Intestinal Stem Cells. 52nd Annual Meeting of The Pacific Association of Pediatric Surgeons (PAPS 2019), New Zealand.

5. Ya-Hui Tsai, Yun Chen (2018, May). The miRNAs regulating the adherens junction are important for the growth of intestinal stem cells into organoids. 51st Annual Meeting of The Pacific Association of Pediatric Surgeons (PAPS 2018), JAPAN.

6. Ya-Hui Tsai, Yun Chen (2017, Nov). Screening for the miRNAs regulating the proliferation of intestinal stem cells with a lentiviral-based miRNA overexpression library. 15th Congress of the Asian Society of Transplantation, Cebu City, Philippines. MOST 104-2314-B-418-015.

7. Ya-Hui Tsai, Chee-Chee Koh, Chia-Chi Weng, Yun Chen (2016, Oct). Management of Parenteral Nutrition-Associated Liver Disease in Intestinal Transplant Recipients. , Los Angeles, Oct. 27-29, 2016. The 9 th International Pediatric Intestinal Failure and Rehabilitation Symposium, Los Angeles, USA.

8. Ya-Hui Tsai, Yun Chen (2016, Jun). Investigation on the miRNA signature in retinoic acid-resistant neuroblastoma cells as novel therapeutic targets. Advances in Neuroblastoma Research Congress, Cairns, Queensland, Australia.

9. Yun Chen, Ya-Hui Tsai (2016, Jun). CPEB1 down-regulated the expression of MYCN via tumor-suppressing miRNA let-7 in human neuroblastoma cells. Advances in Neuroblastoma Research Congress, Cairns, Queensland, Australia.

10. Huang-Wen Tsai, Yun Chen, Ya-Hui Tsai (2016, Apr). VS-5584, a novel PI3K/mTOR dual inhibitor, exhibited tumor-suppressing effects in human neuroblastoma cells. . 49th Annual Meeting of the Pacific Association of Pediatric Surgeons– PAPS, Koloa, Hawaii, USA.

11. Ya-Hui Tsai, Yun Chen (2015, Jul). Growth hormone and glutamine exhibited diverse effects on the proliferation and differentiation of intestinal stem cells. XIV International Small Bowel Transplant Symposium, Buenos Aires, Argentina.

12. Yun Chen, Ya-Hui Tsai (2015, Jul). The effects of ascorbic acid and sodium selenite on the proliferative activity of intestinal stem cells. XIV International Small Bowel Transplant Symposium, Buenos Aires, Argentina.

13. Ya-Hui Tsai, Yun Chen (2015, May). Ascorbic acid (Vitamin C) promotes the proliferative activity of intestinal stem cells. The 48th Annual Meeting of the Pacific Association of Pediatric Surgeons (PAPS2015). Jeju Island, Korea.

14. Yun Chen, Ya-Hui Tsai (2015, May). CPEB1 inhibits the activity of MMP-2 in neuroblastoma cells through up-regulation of miR-21. The 48th Annual Meeting of the Pacific Association of Pediatric Surgeons (PAPS2015). Jeju Island, Korea.

15. Yun Chen, Chee-Chee Koh, Chia-Chi. Weng, J. Wu, B. Chang, Y. Tsai, S. Chu (2015, Mar). The first series of pediatric intestinal transplantation in Taiwan, IPTA 8th International Congress. San Francisco, USA.

16. Ya-Hui Tsai, Yun Chen (2014, Jun). The Therapeutic Effect and Related Mechanisms of AZD8055 Treatment in Neuroblastoma Cells. The 47th Annual Meeting of the Pacific Association of Pediatric Surgeons (PAPS 2014). Banff, Canada.

17. Hsin-Yen Pan, Ya-Hui Tsai, Yun Chen (2014, May). The upregulation of RECK after Valproic acid treatment can induce ER stress response and increase cisplatin cytotoxicity in human neuroblastoma cells. The 47th Annual Meeting of the Pacific Association of Pediatric Surgeons (PAPS 2014). Banff, Canada.

18. Yun Chen, Ya-Hui Tsai (2014, May). The role of CPEB4 in the tumorigenesis of neuroblastomas. The 47th Annual Meeting of the Pacific Association of Pediatric Surgeons (PAPS 2014). Banff, Canada.

19. Ya-Hui Tsai, Yun Chen, Sheng-Hong Tseng (2012, Jun). Micro RNA-21 Regulates the Cisplatin Resistance in Human Neuroblastoma Cell. Advances in Neuroblastoma Research Conference 2012. Toronto, Canada.

20. Ya-Hui Tsai, Yun Chen (2011, Sep). Ischemic preconditioning increases the intestinal stem cells and facilitates the regeneration of intestinal epithelial cells during injury. XII International Small Bowel Transplant Symposium. Washington, USA.